Dr. David Barker first popularized the concept of fetal origins of adult disease (FOAD). Since its inception, FOAD has received considerable attention. The FOAD hypothesis holds that events during early development have a profound impact on one’s risk for development of future adult disease. Low Cited by: 360.
Aug 22, 2012 · The fetal origins of adult disease (FOAD) hypothesis suggests that risk factors from intrauterine environmental exposures affect the fetus' development during sensitive periods, and increases the risk of specific diseases in adult life. This link was initially observed between prenatal exposures and Cited by: 78.
diseases (hypertension, glucose intolerance, hyperlipidemia) (1,3). The ‘Fetal Origin of Adult Disease (FOAD)’ Hypothesis Barker hypothesized that the associations between small size at birth or during infancy and later CVD reflect permanent effects of fetal undernutrition. The fetus is dependent on the nutrients from the mother and adaptsCited by: 11.
Schematic representing the pathogenesis of Fetal Origins of Adult Disease (FOAD). In-utero malnutrition results in neuroendocrine, pancreatic, skeletal muscle, and adipose tissue dysfunction, and increased food intake and decreased energy expenditure. This leads to increase adiposity and insulin resistance, and ultimately future adult disease.Cited by: 360.
By understanding fetal origin of adult disease, health care professionals and policy makers will make this issue a high health care priority and implement preventive measures and treatment for those at higher risk for chronic diseases. Keywords: Adult disease, Barker’s hypothesis, Epigenetics, Fetal programing.